But he found himself in even more unfamiliar territory with an inspired Anderson's relentless, thudding serve eventually overpowering the 20-time grand slam victor.
Defending champion Federer hadn't been broken since the opening set of his 2017 semifinal victory over Tomas Berdych.
That took great self-belief, he added, knowing that he had never taken a set off 20-time major victor Federer in four previous meetings. Nor had anyone over the last 34 sets Federer had played at the All England Club, until Anderson nicked the third.
The 36-year-old Swiss ace came into Wimbledon as the favourite to win a ninth title and retain his crown from last year. But that turned out to be the least of his worries.
Djokovic, who defeated Nishikori in four sets to reach the semi-finals, added: 'It was the tournament's decision.
Federer uncharacteristically committed a lot of errors of his forehand and series of errors when he Anderson was serving for the match at 12-11 in the final set brought his title defence to an unexpected, early end. He hit 28 aces against Federer, saved 9 of 12 break points and managed to hold his own in the rare, lengthy baseline rallies.
Federer squandered his match point at 5-4 on Anderson's serve in the third set but it seemed like it would only be a matter of time before he moved into the semifinals for the 13th time.
When Anderson broke again in the fourth, Federer was suddenly on the ropes. Federer ended up with more points won than Anderson in this match, but ultimately the difference came down to two unforced errors.
The final set lasted 90 minutes, and it was captivating stuff. Anderson held for 5-all, broke to 6-5 with a violent return victor off a 156kph second serve, then staved off three break points and closed the set with a 214kph ace.
On they went, both holding to love for 10-10, but at 11-11 it was Federer who blinked, a double fault handing Anderson a rare break point which he converted.
"Honestly, I'm not sure", the 20-times Grand Slam champion said when asked where it had all gone wrong. "I felt I was playing better tennis, so that was motivating for me as well to keep at it", said Florida-based Anderson who is applying for US citizenship.
"It's one of those average days you have to try to win the match, and I just couldn't get it done". You need that mindset against Roger.
"That was something I learnt from 2016 where I constantly tried to get back into competition too quickly".
As Kevin Anderson secures South Africa's first shot at a Wimbledon final in more than 30 years, the Sports Minister has congratulated him for his stunning win.
The 24th-seeded Nishikori was able to attack Djokovic's second serve and had a chance to take the lead when he was 0-40 up at 2-2 in the third set.
Later in the match, Djokovic was clearly frustrated and complained of "double standards" when Nishikori was not punished for a racket throw. It's just different. I think this gives Anderson a better chance.
"I felt the first set obviously wasn't great for me". Kei did the same in the fourth set but wasn't warned.
"John I think has got arguably one of the best serves of all time on the tour". "I can't see him losing to Nishikori other than the fact that Novak hasn't had success in slams for a while. But hopefully I have two more matches to play".
Clooney is staying on the Italian island to film a Hulu mini-series based on the classic Joseph Heller novel Catch-22. Clooney, the husband of leading human-rights lawyer Amal Clooney, has a home on the Italian mainland at Lake Como .
This isn't the first Thanos-related internet concoction to make its way online after the release of " Infinity War ", however. Fans were loving the addition by the director and Brolin, and filled the comments with applause and jokes from the movie.
Kylie gave birth to Stormi, her first child with rapper Travis Scott , in February this year after a long-rumoured pregnancy. By Forbes' conservative estimate, Jenner's company is valued at almost US$800 million (AU$1.09 billion).
Monday, activists have been mobilizing against whomever the nominee might be since June 27, when Kennedy announced his retirement. Some protesters had makeshift signs that had been updated with the nominee only minutes after his announcement.
Then the spies set up a website, Facebook page and Twitter account called "DCLeaks" to publish the material, Mr. And they lift the curtain on 21st-century cyber warfare that caught the US government completely unprepared.
We controlled the game, but there's always tension with us, we always concede this early goal and have shocks", Vrsaljko said. Defender Sime Vrsaljko kept the score even by heading a shot off the goal line about 10 minutes before Mandzukic scored.
Ball is life ... and the family of Renard Matthews used his love of the Celtics so others would remember him as they do. A big fan of the Boston Celtics and Kyrie Irving , he was dressed in an Irving jersey with the Celtics on a TV screen.
Ellis has since ruled that Mueller is acting within the scope of his investigation in pursuing charges against Manafort. He has access to a laptop and does not have to wear a jail uniform, either, according to prosecutors.
This led to her feeling insecure about her looks and forcing her to overline her mouth with a lip pencil on a daily basis. The savvy businesswoman launched Kylie Cosmetics amid the hype around her lips.
Hour Ago Shock as Chelsea sack Conte
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African players in France's World Cup team
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Relief as first four Thai boys rescued from flooded cave
Reuters news agency reported that six boys have been rescued, citing a senior member of the medical team involved in the rescue. He has also thanked global experts who helped find the boys. "If you ask me how long it will take, no one can answer that".